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ESR 14: Irene Ponzo
Analysis of G-quadruplexes and DNA-binding proteins on a chip
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LightDyNAmics Research
Scientific Background
Conferences
Scientific Publication
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Irene Ponzo works at Dynamic Biosensors GmbH on a research project focused on the production of DNA G-quadruplexes chips. She studies the behaviour and stability of G-quadruplexes on chip, to characterize interactions between analytes and G-quadruplexes. With the switchSENSE® technology she aims at determining the binding affinity and kinetics of proteins to new DNA lesions, and to study DNA-protein interaction for applications in drug design.
Irene Ponzo graduated in March 2018 in MSc Biotechnology at University of Rome Tor Vergata, with a Master thesis project about the study and characterization of synthetic DNA-based nanodevices controlled by redox inputs, carried out in the Laboratory of Biosensors and Nanomachines headed by Prof. Francesco Ricci. Under the supervision of Dr. Alessandro Porchetta, she has been a Visiting Research Student in the DNA Nanomaterials Group headed by Prof. Hanadi Sleiman at McGill University in Montreal (Canada), from June to August 2018, where she worked on pH-responsive DNA nanocubes.
She has presented a poster in the Aptamers Conference in Bordeau form 28th up to 29th June 2019. The Titel of the poster was "A new surface DNA-based biosensor assay for the kinetic characterization of aptamer folding and interactions " (Co-author were F. Möller and N. Matscheko)
Ponzo, I.; Möller, F.M.; Daub, H.; Matscheko, N. A DNA-Based Biosensor Assay for the Kinetic Characterization of Ion-Dependent Aptamer Folding and Protein Binding. Molecules 2019, 24, 2877 doi.org/10.3390/molecules24162877
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